Study into conolidine has brought about discovery of an opioid receptor in the human body called ACKR3/CXCR7. ACKR3 appears to be the most desired target for conolidine, which also disregards another four classical opioid receptors(3). Conolidine is located in the tabernaemontana divaricata plant, that is during the Apocynaceae relatives. https://bookmarkingdepot.com/story20763228/conoldine-alternative-natural-pain-relief-no-further-a-mystery