Study into conolidine has triggered discovery of an opioid receptor in the human body identified as ACKR3/CXCR7. ACKR3 is apparently the most sought after target for conolidine, which also disregards another 4 classical opioid receptors(3). Conolidine has long been present in the tabernaemontana divaricata plant, that's from the Apocynaceae https://mixbookmark.com/story6465728/fascination-about-conolidin-to-replace-traditional-painkillers