We present a severe case of progressive autoimmune pneumonitis requiring surgical intervention in a patient with the monogenic syndrome. autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED). APECED is caused by loss-of-function mutations in the autoimmune regulator (AIRE) gene. which lead to impaired central immune tolerance and autoimmune organ destruction includin... https://www.tourettebrewing.com/