There exists a release of norepinephrine through the descending inhibitory bulbospinal neurons that binds to alpha-2-receptors while in the dorsal horn to reduce afferent suffering transmission and make analgesia. For that reason, drugs like clonidine that focus on alpha-2 receptors can influence the transmission of discomfort. Applies to clonidine: https://adaml046lgb4.empirewiki.com/user