In this article, we display that conolidine, a natural analgesic alkaloid used in classic Chinese medication, targets ACKR3, thereby furnishing extra proof of the correlation involving ACKR3 and agony modulation and opening alternative therapeutic avenues with the cure of Continual agony. All logos, registered trademarks and service-marks stated on https://josephx035pzw5.wikirecognition.com/user