TAK-243 preferentially sure to UBA1 in excess of the connected E1 enzymes UBA2, UBA3, and UBA6 in intact AML cells. Inhibition of UBA1 with TAK-243 decreased amounts of ubiquitylated proteins, greater markers of proteotoxic pressure and DNA hurt stress. In vivo, TAK-243 lowered leukemic load and qualified leukemic stem cells https://augustineo429bfj1.muzwiki.com/user